Monday, May 3, 2021

high-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

  • 1

    Overington, J. P., Al-Lazikani, B. & Hopkins, A. L. how many drug objectives are there? Nature Rev. Drug Discov. 5, 993–996 (2006).

    CAS  Google scholar 

  • 2

    Imming, P., Sinning, C. & Meyer, A. drugs, their targets and the character and variety of drug targets. Nature Rev. Drug Discov. 5, 821–834 (2006).

    CAS  Google pupil 

  • three

    Owens, J. 2006 drug approvals: discovering the niche. Nature Rev. Drug Discov. 6, 187–187 (2007).

    CAS  Google student 

  • 4

    Baxter, D. F. et al. A novel membrane potential-delicate fluorescent dye improves phone-based mostly assays for ion channels. J. Biomol. reveal. 7, 79–eighty five (2002).

    CAS  PubMed  Google pupil 

  • 5

    Benjamin, E. R. et al. State-based compound inhibition of Nav1.2 sodium channels the usage of the FLIPR Vm dye: on-goal and off-target consequences of distinct pharmacological agents. J. Biomol. display. 11, 29–39 (2006).

    CAS  PubMed  Google scholar 

  • 6

    Lu, Q., Lin, S. & Dunlop, J. in handbook of Assay construction in Drug Discovery. (ed. Minor, L. ok.) 343–356 (CRC, Baco Raton, 2006).

    Google scholar 

  • 7

    Wolfe, C., Fuks, B. & Chatelain, P. Comparative study of membrane capabilities-sensitive fluorescent probes and their use in ion channel screening assays. J. Biomol. monitor. 8, 533–543 (2003).

    Google pupil 

  • 8

    Parihar, A. S. et al. functional analysis of huge conductance Ca2+-activated ok+ channels: ion flux experiences by using atomic absorption spectrometry. Assay Drug Dev. Technol. 1, 647–654 (2003).

    CAS  PubMed  G oogle scholar 

  • 9

    Terstappen, G. C. useful evaluation of native and recombinant ion channels using a high-means nonradioactive rubidium efflux assay. Anal. Biochem. 272, 149–one hundred fifty five (1999).

    CAS  PubMed  Google scholar 

  • 10

    Terstappen, G. C. Nonradioactive rubidium ion efflux assay and its functions in drug discovery and building. Assay Drug Dev. Technol. 2, 553–559 (2004).

    CAS  PubMed  Google pupil 

  • eleven

    Pan, Y. P., Xu, X. H. & Wang, X. L. high throughput screening system of potassium channel regulators. Yao Xue Xue Bao 39, eighty five–88 (2004) (in chinese language).

    CAS  PubMed  Google scholar 

  • 12

    Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. more desirable patch-clamp ideas for top-decision existing recording from cells and telephone-free membrane patches. Pflugers Arch. 391, 85–one hundred (1981).

    CAS  PubMed  Google student 

  • 13

    Asmild, M. et al. Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery. Recept. Channels 9, 49–fifty eight (2003).

    CAS  PubMed  Google student 

  • 14

    Lepple-Wienhues, A., Ferlinz, okay., Seeger, A. & Schafer, A. Flip the tip: an automatic, excessive first-rate, low-cost patch clamp reveal. Recept. Channels 9, 13–17 (2003).

    CAS  PubMed  Google pupil 

  • 15

    Vasilyev, D. V., Merrill, T. L. & Bowlby, M. R. construction of a novel computerized ion channel recording components the usage of "internal-out" whole-telephone membranes. J. Biomol. monitor. 10, 806–813 (2005).

    CAS  PubMed  Google pupil 

  • 16

    Vasylyev, D., Merrill, D., Iwanow, A., Dunlop, J. & Bowlby, M. A novel method for patch clamp automation. Pflugers Arch. 452, 240–247 (2006).

    Google scholar 

  • 17

    Schnizler, okay., Kuster, M., Methfessel, C. & Fejtl, M. The roboocyte: computerized cDNA/mRNA injection and subsequent TEVC recording on Xenopus oocytes in 96-smartly microtiter plates. Recept. Channels 9, forty one–48 (2003).

    CAS  PubMed  Google pupil 

  • 18

    Papke, R. L. Estimation of each the potency and efficacy of α7 nAChR agonists from single-concentration responses. lifestyles Sci. 78, 2812–2819 (2006).

    CAS  PubMed  Google scholar 

  • 19

    Kiss, L. et al. high throughput ion-channel pharmacology: planar-array-based mostly voltage clamp. Assay Drug Dev. Technol. 1, 127–one hundred thirty five (2003).

    CAS  PubMed  Google pupil 

  • 20

    Schroeder, ok., Neagle, B., Trezise, D. J. & Worley, J. Ionworks HT: a brand new excessive-throughput electrophysiology size platform. J. Biomol. display. eight, 50–sixty four (2003). This represents the primary validation of an strategy to the full automation of patch clamping in mammalian cells the use of a perforated patch-clamp structure.

    CAS  PubMed  Goo gle student 

  • 21

    Sorota, S., Zhang, X. S., Margulis, M., Tucker, k. & Priestley, T. Characterization of a hERG screen the use of the IonWorks HT: assessment to a hERG rubidium efflux monitor. Assay Drug Dev. Technol. 3, 47–fifty seven (2005).

    CAS  PubMed  Google scholar 

  • 22

    Bridgland-Taylor, M. H. et al. Optimisation and validation of a medium-throughput electrophysiology-based mostly hERG assay using IonWorks HT. J. Pharmacol. Toxicol. methods 54, 189–199 (2006).

    CAS  PubMed  Google sch olar 

  • 23

    Finkel, A. et al. inhabitants patch clamp improves facts consistency and success prices in the measurement of ionic currents. J. Biomol. monitor. eleven, 488–496 (2006). Describes the 2d-era innovation within the IonWorks platform incorporating the population patch-clamp mode leading to a significant boost in percent success rate and compound throughput.

    CAS  PubMed  Google pupil 

  • 24

    John, V. H. et al. Novel 384-smartly population patch clamp electrophtsiology assays for Ca2+-activated ok+ channels. J. Biomol. screen. 12, 50–60 (2007).

    CAS  PubMed  Google scholar 

  • 25

    Tao, H. et al. automatic tight seal electrophysiology for assessing the potential hERG legal responsibility of pharmaceutical compounds. Assay Drug Dev. Technol. 2, 497–506 (2004). original analyze on the implementation of computerized electrophysiology in assist of preclinical evaluation of cardiac ion-channel legal responsibility of drug candidates.

    CAS  PubMed  Google student 

  • 26

    Xu, J. et al. A benchmark look at with sealchip planar patch-clamp expertise. Assay Drug Dev. Technol. 1, 675–684 (2003). the primary demonstration of computerized patch clamp in mammalian cells reaching the same giga-ohm quality seals to these in manual patch-clamp electrophysiology.

    CAS  PubMed  Google student 

  • 27

    Mathes, C. QPatch: the previous, existing and future of computerized patch clamp. professional Opin. Ther. goals 10, 319–327 (2006).

    CAS  PubMed  Google scholar 

  • 28

    Dubin, A. E. et al. settling on modulators of hERG channel activity the use of the PatchXpress planar patch clamp. J. Biomol. monitor. 10, 168–181 (2005).

    CAS  PubMed  Google student 

  • 29

    Guo, L. & Guthrie, H. automated electrophysiology within the preclinical comparison of medicine for potential QT prolongation. J. Pharmacol. Toxicol. strategies 52, 123–135 (2005).

    CAS  PubMed  Google s cholar 

  • 30

    Kutchinsky, J. et al. Characterization of potassium channel modulators with QPatch automatic patch-clamp expertise: device characteristics and performance. Assay Drug Dev. Technol. 1, 685–693 (2003).

    CAS  PubMed  Google pupil 

  • 31

    Farre, C. et al. automatic ion channel screening: patch clamping made handy. skilled Opin. Ther. aims eleven, 557–565 (2007).

    CAS  PubMed  Google scholar 

  • 32

    Brueggemann, A. et al. Ion channel drug discovery and research: the automated Nano-Patch-Clamp technology. Curr. Drug Discov. Technol. 1, 91–ninety six (2004).

    CAS  PubMed  Google student 

  • 33

    Bruggemann, A. et al. high nice ion channel evaluation on a chip with the NPC expertise. Assay Drug Dev. Technol. 1, 665–673 (2003).

    CAS  PubMed  Google pupil 

  • 34

    Stett, A., Burkhardt, C., Weber, U., van Stiphout, P. & Knott, T. CYTOCENTERING: a novel approach enabling computerized mobile-with the aid of-cellphone patch clamping with the CYTOPATCH chip. Recept. Channels 9, 59–sixty six (2003).

    CAS  PubMed  Google student 

  • 35

    Groot-Kormelink, P. J., Tranter, P. R. & Gosling, M. Maximising the effectivity and utility of automatic planar patch clamp electrophysiology. Eur. Pharm. Rev. 1, 39–45 (2007).

    Google pupil 

  • 36

    Jow, F. et al. Validation of a medium-throughput electrophysiological assay for KCNQ2/three channel enhancers the usage of IonWorks HT. J. Biomol. reveal. 12, 1059–1067 (2007).

    CAS  PubMed  Google scholar 

  • 37

    Virginio, C., Giacometti, A., Aldegheri, L., Rimland, J. M. & Terstappen, G. C. Pharmacological houses of rat α7 nicotinic receptors expressed in native and recombinant mobile programs. Eur. J. Pharmacol. 445, 153–161 (2002).

    CAS  PubMed  Google student 

  • 38

    Williams, M. E. et al. Ric-3 promotes useful expression of the nicotinic acetylcholine receptor α7 subunit in mammalian cells. J. Biol. Chem. 280, 1257–1263 (2005).

    CAS  PubMed  Google student 

  • 39

    Kola, I. & Landis, J. Can the pharmaceutical industry in the reduction of attrition prices? Nature Rev. Drug Discov. 3, 711–715 (2004).

    CAS  Google scholar 

  • forty

    Kramer, J., Sagartz, J. & Morris, D. The software of discovery toxicology and pathology in opposition t the design of safer pharmaceutical lead candidates. Nature Rev. Drug Discov. 6, 636–649 (2007).

    CAS  Google pupil 

  • 41

    Preziosi, P. Science, pharmacoeconomics and ethics in drug R.&D: a sustainable future scenario? Nature Rev. Drug Discov. three, 521–526 (2004).

    CAS  Google pupil 

  • 42

    Redfern, W. S. et al. Relationships between preclinical cardiac electrophysiology, medical QT interval prolongation and torsade de pointes for a wide range of drugs: facts for a provisional protection margin in drug building. Cardiovasc. Res. 58, 32–forty five (2003). A seminal analyze defining the relationships between preclinical ion-channel pharmacology and expertise for QT interval prolongation in a various range of drug molecules.

    CAS  PubMed  Google student 

  • 43

    Sanguinetti, M. C. & Tristani-Firouzi, M. hERG potassium channels and cardiac arrhythmia. Nature 440, 463–469 (2006).

    CAS  PubMed  Google scholar 

  • forty four

    foreign convention on Harmonisation (ICH). counsel for trade. S7B Nonclinical contrast of the talents for Delayed Ventricular Repolarization (QT Interval Prolongation) by using Human pharmaceuticals. ICH web web site [online], (2005).

  • 45

    Bass, A. S., Tomaselli, G., Bullingham, R. third & Kinter, L. B. medication outcomes on ventricular repolarization: a crucial contrast of the strengths and weaknesses of present methodologies and regulatory practices. J. Pharmacol. Toxicol. methods 52, 12–21 (2005).

    CAS  PubMed  Google pupil 

  • 46

    Friedrichs, G. S., Patmore, L. & Bass, A. Non-medical comparison of ventricular repolarization (ICH S7B): consequences of an meantime survey of international pharmaceutical businesses. J. Pharmacol. Toxicol. methods 52, 6–eleven (2005).

    CAS  PubMed  Google student 

  • 47

    Aronov, A. M. average pharmacophores for uncharged human ether-a-go-go-connected gene (hERG) blockers. J. Med. Chem. forty nine, 6917–6921 (2006).

    CAS  PubMed  Google scholar 

  • 48

    Dubus, E., Ijjaali, I., Petitet, F. & Michel, A. In silico classification of HERG channel blockers: a data-primarily based strategy. ChemMedChem 1, 622–630 (2006).

    CAS  PubMed  Google s cholar 

  • 49

    tune, M. & Clark, M. development and evaluation of an in silico mannequin for hERG binding. J. Chem. Inf. mannequin. forty six, 392–400 (2006).

    CAS  PubMed  Google student 

  • 50

    Finlayson, ok., Turnbull, L., January, C. T., Sharkey, J. & Kelly, J. S. [3H]dofetilide binding to HERG transfected membranes: a possible excessive throughput preclinical display. Eur. J. Pharmacol. 430, 147–148 (2001).

    CAS  PubMed  Google scholar 

  • 51

    Deacon, M. et al. Early contrast of compound QT prolongation effects: a predictive 384-neatly fluorescence polarization binding assay for measuring hERG blockade. J. Pharmacol. Toxicol. strategies 55, 238–247 (2007).

    CAS  PubMed  Google student 

  • fifty two

    Guthrie, H., Livingston, F. S., Gubler, U. & Garippa, R. a place for high-throughput electrophysiology in cardiac safeguard: screening hERG phone strains and novel compounds with the ion works HTTM device. J. Biomol. display. 10, 832–840 (2005).

    CAS  PubMed  Google scholar 

  • fifty three

    Meyer, T., Boven, ok. H., Gunther, E. & Fejtl, M. Micro-electrode arrays in cardiac security pharmacology: a novel device to study QT interval prolongation. Drug Saf. 27, 763–772 (2004).

    CAS  PubMed  Google scholar 

  • fifty four

    Meyer, T., Leisgen, C., Gonser, B. & Gunther, E. QT-screen: excessive-throughput cardiac security pharmacology through extracellular electrophysiology on basic cardiac myocytes. Assay Drug Dev. Technol. 2, 507–514 (2004).

    CAS  PubMed  Google scholar 

  • fifty five

    Bliss, T. & Lomo, T. long-lasting potentiation of synaptic transmission within the dentate area of the anaesthetized rabbit following stimulation of the perforant course. J. Physiol. 232, 331–356 (1973). long-established demonstration of the synaptic property of LTP, a commonly studied cellular mannequin of reminiscence, and now a contemporary center of attention of automation efforts in mind-slice electrophysiology.

    CAS  PubMed  PubMed important  Google student 

  • 56

    Madison, D., Malenka, R. & Nicoll, R. Mechanisms underlying long-term potentiation of synaptic transmission. Ann. Rev. Neurosci. 14, 379–397 (1991).

    CAS  PubMed  Google scholar 

  • fifty seven

    Bliss, T. & Collingridge, G. A synaptic model of reminiscence: lengthy-time period potentiation within the hippocampus. Nature 361, 31–39 (1993).

    CAS  PubMed  Google pupil 

  • fifty eight

    Nicoll, R. & Malenka, R. Expression mechanisms underlying NMDA receptor-based long-time period potentiation. Ann. big apple Acad. Sci. 868, 515–525 (1999).

    CAS  PubMed  Google pupil 

  • 59

    Kemp, N. & Bashir, Z. lengthy-time period depression: a cascade of induction and expression mechanisms. Prog. Neurobiol. 65, 339–365 (2001).

    CAS  PubMed  Google student 

  • 60

    Lynch, M. long-time period potentiation and memory. Physiol. Rev. eighty four, 87–136 (2004).

    CAS  PubMed  Google scholar 

  • 61

    Larson, J., Lynch, G., video games, D. & Seubert, P. variations in synaptic transmission and lengthy-term potentiation in hippocampal slices from younger and aged PDAPP mice. brain Res. 840, 23–35 (1999).

    CAS  PubMed  Google pupil 

  • sixty two

    Jacobsen, J. et al. Early-onset behavioral and synaptic deficits in a mouse mannequin of Alzheimer's sickness. Proc. Natl Acad. Sci. united states 103, 5161–5166 (2006).

    CAS  PubMed  Google pupil 

  • 63

    Picconi, B. et al. Pathological synaptic plasticity in the striatum: implications for Parkinson's ailment. Neurotoxicology 26, 779–783 (2005).

    CAS  PubMed  Google scholar 

  • 64

    Kreitzer, A. & Malenka, R. Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's ailment fashions. Nature 445, 643–647 (2007).

    CAS  PubMed  Google scholar 

  • sixty five

    Coyle, J. Glutamate and schizophrenia: past the dopamine speculation. mobilephone. Mol. Neurobiol. (2006).

  • 66

    Stephan, k., Baldeweg, T. & Friston, k. Synaptic plasticity and dysconnection in schizophrenia. Biol. Psychiatry fifty nine, 929–939 (2006).

    CAS  PubMed  Google student 

  • 67

    McIlWain, H. Praparing Neural Tissues for Metabolic study in Isolation (ed. McIlWain, H.) (Churchill Livingstone, Edinburgh, London & ny, 1975).

    Google student 

  • 68

    Teyler, T. mind slice training: hippocampus. brain Res. Bull. 5, 391–403 (1980).

    CAS  PubMed  Google pupil 

  • sixty nine

    Andersen, P. brain slices — a neurobiological device of expanding usefulness. trends Neurosci. 4, 53–56 (1981).

    Google scholar 

  • 70

    Dingledine, R. brain Slices (ed. Dingledine, R.) (Springer, big apple, 1984).

    Google student 

  • seventy one

    Stopps, M. et al. Design and application of a novel mind slice gadget that makes it possible for impartial electrophysiological recordings from distinctive slices. J. Neurosci. methods 132, 137–148 (2004).

    CAS  PubMed  Google pupil 

  • seventy two

    Huang, C.-W., Hsieh, Y.-J., Tsai, J. & Huang, C.-C. results of lamotrigine on container potentials, propagation, and lengthy-term potentiation in rat prefrontal cortex in multi-electrode recording. J. Neurosci. Res. 83, 1141–1150 (2006).

    CAS  PubMed  Google scholar 

  • 73

    Krause, M. & Jia, Y. Serotonergic modulation of carbachol-triggered rhythmic undertaking in hippocampal slices. Neuropharmacology forty eight, 381–390 (2005).

    CAS  PubMed  Google scholar 

  • 74

    Oka, H., Shimono, ok., Ogawa, R., Sugihara, H. & Taketani, M. a new planar multielectrode array for extracellular recording: application to hippocampal acute slice. J. Neurosci. strategies ninety three, sixty one–67 (1999).

    CAS  PubMed  Google pupil 

  • 75

    Shimono, okay., Baudry, M., Panchenko, V. & Taketani, M. persistent multichannel recordings from organotypic hippocampal slice cultures: coverage from excitotoxic consequences of NMDA by using noncompetitive NMDA antagonists. J. Neurosci. strategies 120, 193–202 (2002).

    CAS  PubMed  Google student 

  • seventy six

    Shimono, okay., Brucher, F., Granger, R., Lynch, G. & Taketani, M. Origins and distribution of cholinergically triggered beta rhythms in hippocampal slices J. Neurosci. 20, 8462–8473 (2000).

    CAS  PubMed  Google scholar 

  • 77

    Egert, U. et al. A novel organotypic lengthy-term culture of the rat hippocampus on substrate-integrated multielectrode arrays. brain Res. Protocols 2, 229–242 (1998).

    CAS  Google student 

  • seventy eight

    Martinoia, S. et al. In vitro cortical neuronal networks as a new high-delicate device for biosensing applications. Biosens. Bioelectron. 20, 2071–2078 (2005).

    CAS  PubMed  Google scholar 

  • seventy nine

    Potter, S. & DeMarse, T. a brand new strategy to neural mobile lifestyle for long-term studies. J. Neurosci. strategies 110, 17–24 (2001).

    CAS  PubMed  Google scholar 

  • 80

    van Pelt, J., corner, M., Wolters, P., Rutten, W. & Ramakers, G. Longterm balance and developmental adjustments in spontaneous community burst firing patterns in dissociated rat cerebral cortex mobilephone cultures on microeloectrode arrays. Neurosci. Lett. 361, 86–89 (2004).

    CAS  PubMed  Google scholar 

  • 81

    Morin, F., Takamura, Y. & Tamiya, E. Investigating neuronal undertaking with planar microelectrode arrays: achievements and new perspectives. J. Biosci. Bioeng. one hundred, 131–143 (2005).

    CAS  PubMed  Google student 

  • eighty two

    van Pelt, J., Vajda, I., Wolters, P., corner, M. & Ramakers, G. Dynamics and plasticity in establishing neuronal networks in vitro. Prog. mind Res. 147, 173–188 (2005).

    PubMed  Google pupil 

  • 83

    Wagenaar, D., Madhavan, R., Pine, J. & Potter, S. Controlling bursting in cortical cultures with closed-loop multi-electrode stimulation. J. Neurosci. 25, 680–688 (2005).

    CAS  PubMed  PubMed important  Google pupil 

  • eighty four

    Stacy, R., Demas, J., Burgess, R., Sanes, J. & Wong, R. Disruption and recuperation of patterned retinal activity in the absence of acetylcholine. J. Neurosci. 25, 9347–9357 (2005).

    CAS  PubMed  Google pupil 

  • eighty five

    Ishikane, H., Gangi, M., Honda, S. & Tachibana, M. Synchronized retinal oscillations encode elementary guidance for get away behavior in frogs. Nature Neurosci. eight, 1087–1095 (2005).

    CAS  PubMed  Google student 

  • 86

    Haraguchi, Y., Shimizu, T., Yamato, M., Kikuchi, A. & Okano, T. Electrical coupling of cardiomyocyte sheets happens hastily by means of purposeful hole junction formation. Biomaterials 27, 4765–4774 (2006).

    CAS  PubMed  Google student 

  • 87

    Reppel, M., Boettinger, C. & Hescheler, J. β-Adrenergic and muscarinic modulation of human embryonic stem phone-derived cardiomyocytes. cell Physiol. Biochem. 14, 187–196 (2004).

    CAS  PubMed  Google student 

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